Development of pre-candidates with new mechanisms of action against invasive non-typhoidal Salmonella

Duration: January 2025–December 2028

General objective of the project: Identification of new preclinical candidates against invasive non-typhoidal Salmonella (iNTS).

Specific objectives of the project:

  • O1: Discovery of new preclinical candidates with novel mechanisms of action against invasive non-typhoidal Salmonella (iNTS).
  • O2: Development of the necessary tools for the discovery of new drugs against Salmonella iNTS, including new screening assays based on morphological changes.
  • O3: Identification of new mechanisms of action against this pathogen.
  • O4: Determination of the spectrum of action of preclinical candidate antibodies in cell types such as fibroblasts, where Salmonella iNTS persistence has been described.

Work plan: To identify new candidate antibodies that act against Salmonella iNTS through novel mechanisms of action, this consortium will focus on two complementary strategies, identifying new mechanisms of action against intracellular Salmonella and against the host through immunomodulatory mechanisms. These two joint strategies will allow the identification of new mechanisms of action for which there is no prior resistance, while also providing active starting compounds that, after optimization of their properties, will become candidate molecules for subsequent clinical studies against invasive non-typhoidal Salmonellosis.

Consortium members:

This project has been funded by the CDTI, with support from the Ministry of Science, Innovation and Universities.