Custom Synthesis business line is intended to provide clients with scaffolds, building blocks, pharmacological standards, reference standards, metabolites, impurities, etc., that are not commercially available.
AIMS
· 50 g of a competitor’s standard required by mid-size pharma for in vivo assays.
· Patented route for the product described a 0.2% yield in 6 steps.
ACTIONS
· Several alternatives developed for the synthesis of the required fragments.
· Dozens of reaction conditions tried for each critical step.
· Exploration of different approaches suitable for scale-up.
ACHIEVEMENTS
· Three new synthesis routes developed.
· Preferred new route delivered grams in 6 steps with 61% yield using cheaper materials.
· New routes patented to block competitor’s IP.
