It is curious how these things happen. These last weeks I have been checking old entries of the blog, and I saw that there are more and more papers related with the introduction of fluorine: fluorination, deoxyfluorination, trifluoromethylation… The tags in the blog make the search easier than in the previous newsletter format (still available through our website). So I thought it would be a good idea to start compiling a sort of ‘dynamic review’, in the form of a post about fluorination, trifluoromethylation and whateverfluorination methods than could be updated each time a new interesting paper comes up.
Well, Tobias Ritter has saved me the effort. He is one of the experts in the field (see a very recent post about his new trifluoromethylation reagent, PhenoFluorMix), and along with Constanze Neumann has published a review about fluorination methods in the last stage: that is, not the usual methods to introduce the fluorinated stuff into your building block or scaffold, but into your final compound. That one you that is OK in the assay, but you would like to boost a bit, as we said recently.
Late-Stage Fluorination: Fancy Novelty or Useful Tool?
Angew. Chem. Int. Ed. 2015, online version.
See: 10.1002/anie.201410288
Freak Corner. I love the Fluorination Wizard graphic they have used for the TOC. No idea who came with the idea, but it is really appealing to RPG fans. I just hope not needing to do Fluorination rolls with d10 in the lab.
