Bioisosteres are the daily bread for medicinal chemists, though isosterism is in fact an old concept. The title of this review by Meanwell, «Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design», says everything. Not only the review will serve as reminder of some basic concepts and ideas, but also to see how some common problems are tackled.
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
J. Med. Chem. 2011, 54 (8), pp 2529-2591.
See: 10.1021/jm1013693
